Dimple D Rajgor, Meng Har Lee, Sophia Archuleta, Natasha Bagdasarian, Swee Chye Quek
Published: March 27, 2020
The trend in mortality reporting for COVID-19 has been typical for emerging infectious diseases. The case fatality rate (CFR) was reported to be 15% (six of 41 patients) in the initial period, but this estimate was calculated from a small cohort of hospitalised patients. Subsequently, with more data emerging, the CFR decreased to between 4·3% and 11·0%, and later to 3·4%. The rate reported outside China in February was even lower (0·4%; two of 464).
However, several factors can restrict obtaining an accurate estimate of the CFR. The virus and its clinical course are new, and we still have little information about them. Health care capacity and capability factors, including the availability of health-care workers, resources, facilities, and preparedness, also affect outcomes. For example, some countries are able to invest resources into contact tracing and containing the spread through quarantine and isolation of infected or suspected cases. In Singapore, where these measures have been implemented, the CFR of 631 cases (as of March 25, 2020) is 0·3%.
A major challenge with accurate calculation of the CFR is the denominator: the number of people who are infected with the virus. Asymptomatic cases of COVID-19, patients with mild symptoms, or individuals who are misdiagnosed could be left out of the denominator, leading to its underestimation and overestimation of the CFR.
A unique situation has arisen for quite an accurate estimate of the CFR of COVID-19. Among individuals onboard the Diamond Princess cruise ship, data on the denominator are fairly robust. The outbreak of COVID-19 led passengers to be quarantined between Jan 20, and Feb 29, 2020. This scenario provided a population living in a defined territory without most other confounders, such as imported cases, defaulters of screening, or lack of testing capability. 3711 passengers and crew were onboard, of whom 705 became sick and tested positive for COVID-19 and seven died, giving a CFR of 0·99%. If the passengers onboard were generally of an older age, the CFR in a healthy, younger population could be lower.
The Lancet – DOI: https://doi.org/10.1016/S1473-3099(20)30244-9
p.s.: heute – Zahl der Coronavirus-Infektionen: https://twitter.com/OlafGersemann/status/1244495134185721856/photo/1