Fei Zhou, MD Ting Yu, MD Ronghui Du, MD Guohui Fan, MS Ying Liu, MD Zhibo Liu, MD et al.
Published: March 11, 2020
Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p<0·0001), and d-dimer greater than 1 µg/L (18·42, 2·64–128·55; p=0·0033) on admission.
Median duration of viral shedding was 20·0 days (IQR 17·0–24·0) in survivors, but SARS-CoV-2 was detectable until death in non-survivors. The longest observed duration of viral shedding in survivors was 37 days.
…Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
The Lancet – DOI: https://doi.org/10.1016/S0140-6736(20)30566-3